The "full lockdown" will be in place between April 13 and April 22, read a statement from the Autonomous Administration of North and East Syria (AANES) published on Sunday.
Pharmacies, hospitals, humanitarian organisations, media professionals, bakeries, and petrol stations will be exempt from the ban; grocery shops are allowed to be open from 8 am until 5 am.
Entry into Rojava through border crossings will be prohibited for most. There are some commercial, humanitarian, and medical exemptions from the ban.
The AANES health board said on Sunday that it had recorded 298 new coronavirus cases and three deaths in 24 hours. Rojava has recorded 12,236 coronavirus cases, including 1,365 recoveries and 422 deaths, since the start of the pandemic.
The AANES announced some new lockdown measures last week because of a "third wave" of coronavirus infections.
The measures included a full lockdown in the cities of Raqqa, Qamishli, and Hasaka for one week, and a partial lockdown outside of cities.
Rojava is expected to receive its first doses of vaccines, distributed through the COVAX scheme, later this month or in May. According to the World Health Organization (WHO), 136,000 vaccine doses will be sent to Rojava.
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